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Oxygenation to improve cancer vaccines, adoptive cell transfer and blockade of immunological negative regulators

Oxygenation of tumors weakens the tumor-protecting immunosuppressive signaling by A2A adenosine receptors in hypoxic and extracellular adenosine-rich microenvironments. This, in turn, unleashes the otherwise inhibited tumor-reactive T and natural killer (NK) cells. Oxygenation of tumors thus emerges...

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Publicat a:Oncoimmunology
Autors principals: Hatfield, Stephen M, Sitkovsky, Michail
Format: Artigo
Idioma:Inglês
Publicat: Taylor & Francis 2015
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4635883/
https://ncbi.nlm.nih.gov/pubmed/26587328
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/2162402X.2015.1052934
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