CAR-T cells are serial killers

Chimeric antigen receptor (CAR) T cells have enjoyed unprecedented clinical success against haematological malignancies in recent years. However, several aspects of CAR T cell biology remain unknown. We recently compared CAR and T cell receptor (TCR)-based killing in the same effector cell and showe...

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Pubblicato in:Oncoimmunology
Autori principali: Davenport, Alexander J, Jenkins, Misty R, Ritchie, David S, Prince, H Miles, Trapani, Joseph A, Kershaw, Michael H, Darcy, Phillip K, Neeson, Paul J
Natura: Artigo
Lingua:Inglês
Pubblicazione: Taylor & Francis 2015
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4635863/
https://ncbi.nlm.nih.gov/pubmed/26587330
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/2162402X.2015.1053684
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