Persistence and Efficacy of Second Generation CAR T Cell Against the LeY Antigen in Acute Myeloid Leukemia

In a phase I study of autologous chimeric antigen receptor (CAR) anti-LeY T-cell therapy of acute myeloid leukemia (AML), we examined the safety and postinfusion persistence of adoptively transferred T cells. Following fludarabine-containing preconditioning, four patients received up to 1.3 × 109 to...

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Detalhes bibliográficos
Main Authors: Ritchie, David S., Neeson, Paul J., Khot, Amit, Peinert, Stefan, Tai, Tsin, Tainton, Kellie, Chen, Karen, Shin, Mandy, Wall, Dominic M., Hönemann, Dirk, Gambell, Peter, Westerman, David A., Haurat, Javier, Westwood, Jennifer A., Scott, Andrew M., Kravets, Lucy, Dickinson, Michael, Trapani, Joseph A., Smyth, Mark J., Darcy, Phillip K., Kershaw, Michael H., Prince, H. Miles
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2013
Assuntos:
Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3831035/
https://ncbi.nlm.nih.gov/pubmed/23831595
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2013.154
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