Persistence and Efficacy of Second Generation CAR T Cell Against the LeY Antigen in Acute Myeloid Leukemia

In a phase I study of autologous chimeric antigen receptor (CAR) anti-LeY T-cell therapy of acute myeloid leukemia (AML), we examined the safety and postinfusion persistence of adoptively transferred T cells. Following fludarabine-containing preconditioning, four patients received up to 1.3 × 109 to...

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Autori principali: Ritchie, David S., Neeson, Paul J., Khot, Amit, Peinert, Stefan, Tai, Tsin, Tainton, Kellie, Chen, Karen, Shin, Mandy, Wall, Dominic M., Hönemann, Dirk, Gambell, Peter, Westerman, David A., Haurat, Javier, Westwood, Jennifer A., Scott, Andrew M., Kravets, Lucy, Dickinson, Michael, Trapani, Joseph A., Smyth, Mark J., Darcy, Phillip K., Kershaw, Michael H., Prince, H. Miles
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2013
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Original Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3831035/
https://ncbi.nlm.nih.gov/pubmed/23831595
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2013.154
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