Persistence and Efficacy of Second Generation CAR T Cell Against the LeY Antigen in Acute Myeloid Leukemia

In a phase I study of autologous chimeric antigen receptor (CAR) anti-LeY T-cell therapy of acute myeloid leukemia (AML), we examined the safety and postinfusion persistence of adoptively transferred T cells. Following fludarabine-containing preconditioning, four patients received up to 1.3 × 109 to...

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Bibliografski detalji
Glavni autori: Ritchie, David S., Neeson, Paul J., Khot, Amit, Peinert, Stefan, Tai, Tsin, Tainton, Kellie, Chen, Karen, Shin, Mandy, Wall, Dominic M., Hönemann, Dirk, Gambell, Peter, Westerman, David A., Haurat, Javier, Westwood, Jennifer A., Scott, Andrew M., Kravets, Lucy, Dickinson, Michael, Trapani, Joseph A., Smyth, Mark J., Darcy, Phillip K., Kershaw, Michael H., Prince, H. Miles
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group 2013
Teme:
Original Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3831035/
https://ncbi.nlm.nih.gov/pubmed/23831595
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2013.154
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