Adoptive transfer of T cells modified with a humanized chimeric receptor gene inhibits growth of Lewis-Y-expressing tumors in mice

In this study, human T cells were provided with a reactivity against the Lewis-Y (Le(Y)) carbohydrate antigen, which is overexpressed on 70% of epithelial-derived tumors, but not normally recognized by T cells. Antitumor reactivity was achieved by transduction of T cells with a gene encoding a cell-...

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Bibliografiske detaljer
Main Authors: Westwood, Jennifer A., Smyth, Mark J., Teng, Michele W. L., Moeller, Maria, Trapani, Joseph A., Scott, Andrew M., Smyth, Fiona E., Cartwright, Glenn A., Power, Barbara E., Hönemann, Dirk, Prince, H. Miles, Darcy, Phillip K., Kershaw, Michael H.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2005
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1323148/
https://ncbi.nlm.nih.gov/pubmed/16365285
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0504312102
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