Adoptive transfer of T cells modified with a humanized chimeric receptor gene inhibits growth of Lewis-Y-expressing tumors in mice

In this study, human T cells were provided with a reactivity against the Lewis-Y (Le(Y)) carbohydrate antigen, which is overexpressed on 70% of epithelial-derived tumors, but not normally recognized by T cells. Antitumor reactivity was achieved by transduction of T cells with a gene encoding a cell-...

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Hlavní autoři: Westwood, Jennifer A., Smyth, Mark J., Teng, Michele W. L., Moeller, Maria, Trapani, Joseph A., Scott, Andrew M., Smyth, Fiona E., Cartwright, Glenn A., Power, Barbara E., Hönemann, Dirk, Prince, H. Miles, Darcy, Phillip K., Kershaw, Michael H.
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2005
Témata:
Biological Sciences
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1323148/
https://ncbi.nlm.nih.gov/pubmed/16365285
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0504312102
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