Adoptive transfer of T cells modified with a humanized chimeric receptor gene inhibits growth of Lewis-Y-expressing tumors in mice

In this study, human T cells were provided with a reactivity against the Lewis-Y (Le(Y)) carbohydrate antigen, which is overexpressed on 70% of epithelial-derived tumors, but not normally recognized by T cells. Antitumor reactivity was achieved by transduction of T cells with a gene encoding a cell-...

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Autors principals: Westwood, Jennifer A., Smyth, Mark J., Teng, Michele W. L., Moeller, Maria, Trapani, Joseph A., Scott, Andrew M., Smyth, Fiona E., Cartwright, Glenn A., Power, Barbara E., Hönemann, Dirk, Prince, H. Miles, Darcy, Phillip K., Kershaw, Michael H.
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2005
Matèries:
Biological Sciences
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC1323148/
https://ncbi.nlm.nih.gov/pubmed/16365285
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0504312102
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