H7N9 T-cell epitopes that mimic human sequences are less immunogenic and may induce Treg-mediated tolerance

Avian-origin H7N9 influenza is a novel influenza A virus (IAV) that emerged in humans in China in 2013. Using immunoinformatics tools, we identified several H7N9 T cell epitopes with T cell receptor (TCR)-facing residues identical to those of multiple epitopes from human proteins. We hypothesized th...

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Detalhes bibliográficos
Publicado no:Hum Vaccin Immunother
Main Authors: Liu, Rui, Moise, Leonard, Tassone, Ryan, Gutierrez, Andres H, Terry, Frances E, Sangare, Kotou, Ardito, Matthew T, Martin, William D, De Groot, Anne S
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2015
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4635734/
https://ncbi.nlm.nih.gov/pubmed/26090577
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/21645515.2015.1052197
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