Conservation of HIV-1 T cell epitopes across time and clades: Validation of immunogenic HLA-A2 epitopes selected for the GAIA HIV vaccine

HIV genomic sequence variability has complicated efforts to generate an effective globally relevant vaccine. Regions of the viral genome conserved in sequence and across time may represent the “Achilles’ heel” of HIV. In this study, highly conserved T-cell epitopes were selected using immunoinformat...

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Detalhes bibliográficos
Main Authors: Levitz, Lauren, Koita, Ousmane A., Sangare, Kotou, Ardito, Matthew T., Boyle, Christine M., Rozehnal, John, Tounkara, Karamoko, Dao, Sounkalo M., Koné, Youssouf, Koty, Zoumana, Buus, Soren, Moise, Leonard, Martin, William D., De Groot, Anne S.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3522424/
https://ncbi.nlm.nih.gov/pubmed/23102976
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.vaccine.2012.10.042
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