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Re-expression of LKB1 in LKB1-mutant EKVX cells leads to resistance to paclitaxel through the up-regulation of MDR1 expression
OBJECTIVES: The tumor suppressor LKB1 has recently been shown to be involved in the regulation of microtubule dynamics, thus cancer cells with inactivated LKB1 may have developed a means to overcome dysregulated microtubule functions, making them intrinsically resistant to microtubule targeting agen...
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| Publicado en: | Lung Cancer |
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| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2015
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4635671/ https://ncbi.nlm.nih.gov/pubmed/25769882 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.lungcan.2015.02.017 |
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