Omeprazole Attenuates Pulmonary Aryl Hydrocarbon Receptor Activation and Potentiates Hyperoxia-Induced Developmental Lung Injury in Newborn Mice

Hyperoxia contributes to the development of bronchopulmonary dysplasia (BPD) in human preterm infants and a similar lung phenotype characterized by alveolar simplification in newborn mice. Omeprazole (OM) is a proton pump inhibitor that is used to treat humans with gastric acid related disorders. OM...

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Bibliographic Details
Published in:Toxicol Sci
Main Authors: Shivanna, Binoy, Zhang, Shaojie, Patel, Ananddeep, Jiang, Weiwu, Wang, Lihua, Welty, Stephen E., Moorthy, Bhagavatula
Format: Artigo
Language:Inglês
Published: Oxford University Press 2015
Subjects:
Divergent Effects of Omeprazole in Models of Pulmonary Damage
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4635634/
https://ncbi.nlm.nih.gov/pubmed/26272953
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/toxsci/kfv183
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