Integrated Model of Chemical Perturbations of a Biological Pathway Using 18 In Vitro High-Throughput Screening Assays for the Estrogen Receptor

We demonstrate a computational network model that integrates 18 in vitro, high-throughput screening assays measuring estrogen receptor (ER) binding, dimerization, chromatin binding, transcriptional activation, and ER-dependent cell proliferation. The network model uses activity patterns across the i...

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Bibliografske podrobnosti
izdano v:Toxicol Sci
Main Authors: Judson, Richard S., Magpantay, Felicia Maria, Chickarmane, Vijay, Haskell, Cymra, Tania, Nessy, Taylor, Jean, Xia, Menghang, Huang, Ruili, Rotroff, Daniel M., Filer, Dayne L., Houck, Keith A., Martin, Matthew T., Sipes, Nisha, Richard, Ann M., Mansouri, Kamel, Setzer, R. Woodrow, Knudsen, Thomas B., Crofton, Kevin M., Thomas, Russell S.
Format: Artigo
Jezik:Inglês
Izdano: Oxford University Press 2015
Teme:
Integration of Data from Multiple HTS Screens
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4635633/
https://ncbi.nlm.nih.gov/pubmed/26272952
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/toxsci/kfv168
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