Integrated Model of Chemical Perturbations of a Biological Pathway Using 18 In Vitro High-Throughput Screening Assays for the Estrogen Receptor

We demonstrate a computational network model that integrates 18 in vitro, high-throughput screening assays measuring estrogen receptor (ER) binding, dimerization, chromatin binding, transcriptional activation, and ER-dependent cell proliferation. The network model uses activity patterns across the i...

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Detalhes bibliográficos
Publicado no:Toxicol Sci
Main Authors: Judson, Richard S., Magpantay, Felicia Maria, Chickarmane, Vijay, Haskell, Cymra, Tania, Nessy, Taylor, Jean, Xia, Menghang, Huang, Ruili, Rotroff, Daniel M., Filer, Dayne L., Houck, Keith A., Martin, Matthew T., Sipes, Nisha, Richard, Ann M., Mansouri, Kamel, Setzer, R. Woodrow, Knudsen, Thomas B., Crofton, Kevin M., Thomas, Russell S.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2015
Assuntos:
Integration of Data from Multiple HTS Screens
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4635633/
https://ncbi.nlm.nih.gov/pubmed/26272952
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/toxsci/kfv168
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