Integrated Model of Chemical Perturbations of a Biological Pathway Using 18 In Vitro High-Throughput Screening Assays for the Estrogen Receptor

We demonstrate a computational network model that integrates 18 in vitro, high-throughput screening assays measuring estrogen receptor (ER) binding, dimerization, chromatin binding, transcriptional activation, and ER-dependent cell proliferation. The network model uses activity patterns across the i...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Toxicol Sci
Prif Awduron: Judson, Richard S., Magpantay, Felicia Maria, Chickarmane, Vijay, Haskell, Cymra, Tania, Nessy, Taylor, Jean, Xia, Menghang, Huang, Ruili, Rotroff, Daniel M., Filer, Dayne L., Houck, Keith A., Martin, Matthew T., Sipes, Nisha, Richard, Ann M., Mansouri, Kamel, Setzer, R. Woodrow, Knudsen, Thomas B., Crofton, Kevin M., Thomas, Russell S.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Oxford University Press 2015
Pynciau:
Integration of Data from Multiple HTS Screens
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4635633/
https://ncbi.nlm.nih.gov/pubmed/26272952
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/toxsci/kfv168
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