Using ToxCast™ Data to Reconstruct Dynamic Cell State Trajectories and Estimate Toxicological Points of Departure

BACKGROUND: High-content imaging (HCI) allows simultaneous measurement of multiple cellular phenotypic changes and is an important tool for evaluating the biological activity of chemicals. OBJECTIVES: Our goal was to analyze dynamic cellular changes using HCI to identify the “tipping point” at which...

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Detalhes bibliográficos
Publicado no:Environ Health Perspect
Main Authors: Shah, Imran, Setzer, R. Woodrow, Jack, John, Houck, Keith A., Judson, Richard S., Knudsen, Thomas B., Liu, Jie, Martin, Matthew T., Reif, David M., Richard, Ann M., Thomas, Russell S., Crofton, Kevin M., Dix, David J., Kavlock, Robert J.
Formato: Artigo
Idioma:Inglês
Publicado em: National Institute of Environmental Health Sciences 2015
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4937847/
https://ncbi.nlm.nih.gov/pubmed/26473631
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1289/ehp.1409029
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