Using ToxCast™ Data to Reconstruct Dynamic Cell State Trajectories and Estimate Toxicological Points of Departure

BACKGROUND: High-content imaging (HCI) allows simultaneous measurement of multiple cellular phenotypic changes and is an important tool for evaluating the biological activity of chemicals. OBJECTIVES: Our goal was to analyze dynamic cellular changes using HCI to identify the “tipping point” at which...

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Bibliografiske detaljer
Udgivet i:Environ Health Perspect
Main Authors: Shah, Imran, Setzer, R. Woodrow, Jack, John, Houck, Keith A., Judson, Richard S., Knudsen, Thomas B., Liu, Jie, Martin, Matthew T., Reif, David M., Richard, Ann M., Thomas, Russell S., Crofton, Kevin M., Dix, David J., Kavlock, Robert J.
Format: Artigo
Sprog:Inglês
Udgivet: National Institute of Environmental Health Sciences 2015
Fag:
Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4937847/
https://ncbi.nlm.nih.gov/pubmed/26473631
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1289/ehp.1409029
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