Using ToxCast™ Data to Reconstruct Dynamic Cell State Trajectories and Estimate Toxicological Points of Departure

BACKGROUND: High-content imaging (HCI) allows simultaneous measurement of multiple cellular phenotypic changes and is an important tool for evaluating the biological activity of chemicals. OBJECTIVES: Our goal was to analyze dynamic cellular changes using HCI to identify the “tipping point” at which...

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Publicado en:Environ Health Perspect
Autores principales: Shah, Imran, Setzer, R. Woodrow, Jack, John, Houck, Keith A., Judson, Richard S., Knudsen, Thomas B., Liu, Jie, Martin, Matthew T., Reif, David M., Richard, Ann M., Thomas, Russell S., Crofton, Kevin M., Dix, David J., Kavlock, Robert J.
Formato: Artigo
Lenguaje:Inglês
Publicado: National Institute of Environmental Health Sciences 2015
Materias:
Research
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4937847/
https://ncbi.nlm.nih.gov/pubmed/26473631
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1289/ehp.1409029
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