Integrated Model of Chemical Perturbations of a Biological Pathway Using 18 In Vitro High-Throughput Screening Assays for the Estrogen Receptor

We demonstrate a computational network model that integrates 18 in vitro, high-throughput screening assays measuring estrogen receptor (ER) binding, dimerization, chromatin binding, transcriptional activation, and ER-dependent cell proliferation. The network model uses activity patterns across the i...

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Bibliografische gegevens
Gepubliceerd in:Toxicol Sci
Hoofdauteurs: Judson, Richard S., Magpantay, Felicia Maria, Chickarmane, Vijay, Haskell, Cymra, Tania, Nessy, Taylor, Jean, Xia, Menghang, Huang, Ruili, Rotroff, Daniel M., Filer, Dayne L., Houck, Keith A., Martin, Matthew T., Sipes, Nisha, Richard, Ann M., Mansouri, Kamel, Setzer, R. Woodrow, Knudsen, Thomas B., Crofton, Kevin M., Thomas, Russell S.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Oxford University Press 2015
Onderwerpen:
Integration of Data from Multiple HTS Screens
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4635633/
https://ncbi.nlm.nih.gov/pubmed/26272952
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/toxsci/kfv168
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