In vitro and in vivo single-agent efficacy of checkpoint kinase inhibition in acute lymphoblastic leukemia

BACKGROUND: Although progress in children, in adults, ALL still carries a dismal outcome. Here, we explored the in vitro and in vivo activity of PF-00477736 (Pfizer), a potent, selective ATP-competitive small-molecule inhibitor of checkpoint kinase 1 (Chk1) and with lower efficacy of checkpoint kina...

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Bibliografische gegevens
Gepubliceerd in:J Hematol Oncol
Hoofdauteurs: Iacobucci, Ilaria, Di Rorà, Andrea Ghelli Luserna, Falzacappa, Maria Vittoria Verga, Agostinelli, Claudio, Derenzini, Enrico, Ferrari, Anna, Papayannidis, Cristina, Lonetti, Annalisa, Righi, Simona, Imbrogno, Enrica, Pomella, Silvia, Venturi, Claudia, Guadagnuolo, Viviana, Cattina, Federica, Ottaviani, Emanuela, Abbenante, Maria Chiara, Vitale, Antonella, Elia, Loredana, Russo, Domenico, Zinzani, Pier Luigi, Pileri, Stefano, Pelicci, Pier Giuseppe, Martinelli, Giovanni
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: BioMed Central 2015
Onderwerpen:
Research
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4635624/
https://ncbi.nlm.nih.gov/pubmed/26542114
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13045-015-0206-5
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