In vitro and in vivo single-agent efficacy of checkpoint kinase inhibition in acute lymphoblastic leukemia

BACKGROUND: Although progress in children, in adults, ALL still carries a dismal outcome. Here, we explored the in vitro and in vivo activity of PF-00477736 (Pfizer), a potent, selective ATP-competitive small-molecule inhibitor of checkpoint kinase 1 (Chk1) and with lower efficacy of checkpoint kina...

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Publicat a:J Hematol Oncol
Autors principals: Iacobucci, Ilaria, Di Rorà, Andrea Ghelli Luserna, Falzacappa, Maria Vittoria Verga, Agostinelli, Claudio, Derenzini, Enrico, Ferrari, Anna, Papayannidis, Cristina, Lonetti, Annalisa, Righi, Simona, Imbrogno, Enrica, Pomella, Silvia, Venturi, Claudia, Guadagnuolo, Viviana, Cattina, Federica, Ottaviani, Emanuela, Abbenante, Maria Chiara, Vitale, Antonella, Elia, Loredana, Russo, Domenico, Zinzani, Pier Luigi, Pileri, Stefano, Pelicci, Pier Giuseppe, Martinelli, Giovanni
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2015
Matèries:
Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4635624/
https://ncbi.nlm.nih.gov/pubmed/26542114
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13045-015-0206-5
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