Genome-wide DNA methylation profiling of CD8+ T cells shows a distinct epigenetic signature to CD4+ T cells in multiple sclerosis patients

BACKGROUND: Multiple sclerosis (MS) is thought to be a T cell-mediated autoimmune disorder. MS pathogenesis is likely due to a genetic predisposition triggered by a variety of environmental factors. Epigenetics, particularly DNA methylation, provide a logical interface for environmental factors to i...

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Vydáno v:Clin Epigenetics
Hlavní autoři: Maltby, Vicki E., Graves, Moira C., Lea, Rodney A., Benton, Miles C., Sanders, Katherine A., Tajouri, Lotti, Scott, Rodney J., Lechner-Scott, Jeannette
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2015
Témata:
Short Report
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4635618/
https://ncbi.nlm.nih.gov/pubmed/26550040
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13148-015-0152-7
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