Differential methylation at MHC in CD4(+) T cells is associated with multiple sclerosis independently of HLA-DRB1

BACKGROUND: Although many genetic variants have been associated with multiple sclerosis (MS) risk, they do not explain all the disease risk and there remains uncertainty as to how these variants contribute to disease. DNA methylation is an epigenetic mechanism that can influence gene expression and...

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Vydáno v:Clin Epigenetics
Hlavní autoři: Maltby, Vicki E., Lea, Rodney A., Sanders, Katherine A., White, Nicole, Benton, Miles C., Scott, Rodney J., Lechner-Scott, Jeannette
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2017
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Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5516341/
https://ncbi.nlm.nih.gov/pubmed/28729889
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13148-017-0371-1
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