Preventive effect of oral goshajinkigan on chronic oxaliplatin-induced hypoesthesia in rats

Oxaliplatin, a widely used chemotherapeutic agent, induces peripheral neuropathy that manifests itself as two distinct phases: acute cold hyperesthesia and chronic peripheral hypoesthesia/dysesthesia. The latter is a serious dose-limiting side effect that can often lead to withdrawal of treatment. W...

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Опубликовано в: :Sci Rep
Главные авторы: Kono, Toru, Suzuki, Yasuyuki, Mizuno, Keita, Miyagi, Chika, Omiya, Yuji, Sekine, Hitomi, Mizuhara, Yasuharu, Miyano, Kanako, Kase, Yoshio, Uezono, Yasuhito
Формат: Artigo
Язык:Inglês
Опубликовано: Nature Publishing Group 2015
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4635352/
https://ncbi.nlm.nih.gov/pubmed/26542342
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep16078
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