Selective targeting of IRF4 by synthetic microRNA-125b-5p mimics induces anti-multiple myeloma activity in vitro and in vivo

Interferon regulatory factor 4 (IRF4) is an attractive therapeutic target in multiple myeloma (MM). We here report that expression of IRF4 mRNA inversely correlates with microRNA (miR)-125b in MM patients. Moreover, we provide evidence that miR-125b is downregulated in TC2/3 molecular MM subgroups a...

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Veröffentlicht in:Leukemia
Hauptverfasser: Morelli, E, Leone, E, Cantafio, M E Gallo, Di Martino, M T, Amodio, N, Biamonte, L, Gullà, A, Foresta, U, Pitari, M R, Botta, C, Rossi, M, Neri, A, Munshi, N C, Anderson, K C, Tagliaferri, P, Tassone, P
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2015
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Original Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4635336/
https://ncbi.nlm.nih.gov/pubmed/25987254
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/leu.2015.124
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