Parkin represses 6-hydroxydopamine-induced apoptosis via stabilizing scaffold protein p62 in PC12 cells

AIM: Parkin has been shown to exert protective effects against 6-hydroxydopamine (6-OHDA)-induced neurotoxicity in different models of Parkinson disease. In the present study we investigated the molecular mechanisms underlying the neuroprotective action of parkin in vitro. METHODS: HEK293, HeLa and...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Acta Pharmacol Sin
Main Authors: Hou, Xiao-ou, Si, Jian-min, Ren, Hai-gang, Chen, Dong, Wang, Hong-feng, Ying, Zheng, Hu, Qing-song, Gao, Feng, Wang, Guang-hui
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group 2015
Teme:
Original Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4635325/
https://ncbi.nlm.nih.gov/pubmed/26364802
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/aps.2015.54
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