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Mutant Huntingtin and Elusive Defects in Oxidative Metabolism and Mitochondrial Calcium Handling
Elongation of a poly-glutamine (polyQ) stretch in huntingtin protein (Htt) is linked to Huntington’s disease (HD) pathogenesis. The mutation in Htt correlates with neuronal dysfunction in the striatum and cerebral cortex, and eventually leads to neuronal cell death. The exact mechanisms of the injur...
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| Udgivet i: | Mol Neurobiol |
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| Hovedforfatter: | |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2015
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4635103/ https://ncbi.nlm.nih.gov/pubmed/25941077 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s12035-015-9188-0 |
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