Targeting the notch pathway: A potential therapeutic approach for desmoid tumors

BACKGROUND: Desmoid tumors (DTs) are rare mesenchymal lesions that can recur repeatedly. When it is feasible, DTs are surgically resected; however, this often results in high recurrence rates. Recently, treatment with PF‐03084014, a potent γ‐secretase inhibitor, has been shown to have antitumor acti...

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Detalhes bibliográficos
Publicado no:Cancer
Main Authors: Shang, Hui, Braggio, Danielle, Lee, Ya‐Jung, Al Sannaa, Ghadah A., Creighton, Chad J., Bolshakov, Svetlana, Lazar, Alexander J. F., Lev, Dina, Pollock, Raphael E.
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2015
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Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4635059/
https://ncbi.nlm.nih.gov/pubmed/26349011
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cncr.29564
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