Metabolomic Quantitative Trait Loci (mQTL) Mapping Implicates the Ubiquitin Proteasome System in Cardiovascular Disease Pathogenesis

Levels of certain circulating short-chain dicarboxylacylcarnitine (SCDA), long-chain dicarboxylacylcarnitine (LCDA) and medium chain acylcarnitine (MCA) metabolites are heritable and predict cardiovascular disease (CVD) events. Little is known about the biological pathways that influence levels of m...

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Bibliographic Details
Published in:PLoS Genet
Main Authors: Kraus, William E., Muoio, Deborah M., Stevens, Robert, Craig, Damian, Bain, James R., Grass, Elizabeth, Haynes, Carol, Kwee, Lydia, Qin, Xuejun, Slentz, Dorothy H., Krupp, Deidre, Muehlbauer, Michael, Hauser, Elizabeth R., Gregory, Simon G., Newgard, Christopher B., Shah, Svati H.
Format: Artigo
Language:Inglês
Published: Public Library of Science 2015
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4634848/
https://ncbi.nlm.nih.gov/pubmed/26540294
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1005553
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