Metabolomic Quantitative Trait Loci (mQTL) Mapping Implicates the Ubiquitin Proteasome System in Cardiovascular Disease Pathogenesis

Levels of certain circulating short-chain dicarboxylacylcarnitine (SCDA), long-chain dicarboxylacylcarnitine (LCDA) and medium chain acylcarnitine (MCA) metabolites are heritable and predict cardiovascular disease (CVD) events. Little is known about the biological pathways that influence levels of m...

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Pubblicato in:PLoS Genet
Autori principali: Kraus, William E., Muoio, Deborah M., Stevens, Robert, Craig, Damian, Bain, James R., Grass, Elizabeth, Haynes, Carol, Kwee, Lydia, Qin, Xuejun, Slentz, Dorothy H., Krupp, Deidre, Muehlbauer, Michael, Hauser, Elizabeth R., Gregory, Simon G., Newgard, Christopher B., Shah, Svati H.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2015
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4634848/
https://ncbi.nlm.nih.gov/pubmed/26540294
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1005553
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