Phosphatidylserine (PS) Is Exposed in Choroidal Neovascular Endothelium: PS-Targeting Antibodies Inhibit Choroidal Angiogenesis In Vivo and Ex Vivo

PURPOSE: Choroidal neovascularization (CNV) accounts for 90% of cases of severe vision loss in patients with advanced age-related macular degeneration. Identifying new therapeutic targets for CNV may lead to novel combination therapies to improve outcomes and reduce treatment burden. Our goal was to...

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Detalhes bibliográficos
Publicado no:Invest Ophthalmol Vis Sci
Main Authors: Li, Tao, Aredo, Bogale, Zhang, Kaiyan, Zhong, Xin, Pulido, Jose S., Wang, Shusheng, He, Yu-Guang, Huang, Xianming, Brekken, Rolf A., Ufret-Vincenty, Rafael L.
Formato: Artigo
Idioma:Inglês
Publicado em: The Association for Research in Vision and Ophthalmology 2015
Assuntos:
Retina
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4634629/
https://ncbi.nlm.nih.gov/pubmed/26529048
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1167/iovs.15-17302
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