A virosomal respiratory syncytial virus vaccine adjuvanted with monophosphoryl lipid A provides protection against viral challenge without priming for enhanced disease in cotton rats

BACKGROUND: Non‐replicating respiratory syncytial virus (RSV) vaccine candidates could potentially prime for enhanced respiratory disease (ERD) due to a T‐cell‐mediated immunopathology, following RSV infection. Vaccines with built‐in immune response modifiers, such as Toll‐like receptor (TLR) ligand...

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Vydáno v:Influenza Other Respir Viruses
Hlavní autoři: Kamphuis, Tobias, Stegmann, Toon, Meijerhof, Tjarko, Wilschut, Jan, de Haan, Aalzen
Médium: Artigo
Jazyk:Inglês
Vydáno: John Wiley and Sons Inc. 2013
Témata:
Part 3
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4634254/
https://ncbi.nlm.nih.gov/pubmed/23575113
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/irv.12112
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