Notch signal strength controls cell fate in the haemogenic endothelium

Acquisition of the arterial and haemogenic endothelium fates concurrently occur in the aorta–gonad–mesonephros (AGM) region prior to haematopoietic stem cell (HSC) generation. The arterial programme depends on Dll4 and the haemogenic endothelium/HSC on Jag1-mediated Notch1 signalling. How Notch1 dis...

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Vydáno v:Nat Commun
Hlavní autoři: Gama-Norton, Leonor, Ferrando, Eva, Ruiz-Herguido, Cristina, Liu, Zenhy, Guiu, Jordi, Islam, Abul B. M. M. K., Lee, Sung-Uk, Yan, Minhong, Guidos, Cynthia J., López-Bigas, Nuria, Maeda, Takahiro, Espinosa, Lluis, Kopan, Raphael, Bigas, Anna
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Pub. Group 2015
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4634136/
https://ncbi.nlm.nih.gov/pubmed/26465397
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms9510
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