Presynaptic spinophilin tunes neurexin signalling to control active zone architecture and function

Assembly and maturation of synapses at the Drosophila neuromuscular junction (NMJ) depend on trans-synaptic neurexin/neuroligin signalling, which is promoted by the scaffolding protein Syd-1 binding to neurexin. Here we report that the scaffold protein spinophilin binds to the C-terminal portion of...

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Udgivet i:Nat Commun
Main Authors: Muhammad, Karzan, Reddy-Alla, Suneel, Driller, Jan H, Schreiner, Dietmar, Rey, Ulises, Böhme, Mathias A., Hollmann, Christina, Ramesh, Niraja, Depner, Harald, Lützkendorf, Janine, Matkovic, Tanja, Götz, Torsten, Bergeron, Dominique D., Schmoranzer, Jan, Goettfert, Fabian, Holt, Mathew, Wahl, Markus C., Hell, Stefan W., Scheiffele, Peter, Walter, Alexander M., Loll, Bernhard, Sigrist, Stephan J.
Format: Artigo
Sprog:Inglês
Udgivet: Nature Pub. Group 2015
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4633989/
https://ncbi.nlm.nih.gov/pubmed/26471740
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms9362
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