A high affinity RIM-binding protein/Aplip1 interaction prevents the formation of ectopic axonal active zones

Synaptic vesicles (SVs) fuse at active zones (AZs) covered by a protein scaffold, at Drosophila synapses comprised of ELKS family member Bruchpilot (BRP) and RIM-binding protein (RBP). We here demonstrate axonal co-transport of BRP and RBP using intravital live imaging, with both proteins co-accumul...

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Veröffentlicht in:eLife
Hauptverfasser: Siebert, Matthias, Böhme, Mathias A, Driller, Jan H, Babikir, Husam, Mampell, Malou M, Rey, Ulises, Ramesh, Niraja, Matkovic, Tanja, Holton, Nicole, Reddy-Alla, Suneel, Göttfert, Fabian, Kamin, Dirk, Quentin, Christine, Klinedinst, Susan, Andlauer, Till FM, Hell, Stefan W, Collins, Catherine A, Wahl, Markus C, Loll, Bernhard, Sigrist, Stephan J
Format: Artigo
Sprache:Inglês
Veröffentlicht: eLife Sciences Publications, Ltd 2015
Schlagworte:
Neuroscience
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4536467/
https://ncbi.nlm.nih.gov/pubmed/26274777
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.06935
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