Presynaptic spinophilin tunes neurexin signalling to control active zone architecture and function

Assembly and maturation of synapses at the Drosophila neuromuscular junction (NMJ) depend on trans-synaptic neurexin/neuroligin signalling, which is promoted by the scaffolding protein Syd-1 binding to neurexin. Here we report that the scaffold protein spinophilin binds to the C-terminal portion of...

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Pubblicato in:Nat Commun
Autori principali: Muhammad, Karzan, Reddy-Alla, Suneel, Driller, Jan H, Schreiner, Dietmar, Rey, Ulises, Böhme, Mathias A., Hollmann, Christina, Ramesh, Niraja, Depner, Harald, Lützkendorf, Janine, Matkovic, Tanja, Götz, Torsten, Bergeron, Dominique D., Schmoranzer, Jan, Goettfert, Fabian, Holt, Mathew, Wahl, Markus C., Hell, Stefan W., Scheiffele, Peter, Walter, Alexander M., Loll, Bernhard, Sigrist, Stephan J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Pub. Group 2015
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4633989/
https://ncbi.nlm.nih.gov/pubmed/26471740
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms9362
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