Mutation of EMG1 causing Bowen–Conradi syndrome results in reduced cell proliferation rates concomitant with G2/M arrest and 18S rRNA processing delay

Eitemau Tebyg

• Mutation of a Gene Essential for Ribosome Biogenesis, EMG1, Causes Bowen-Conradi Syndrome
  gan: Armistead, Joy, et al.
  Cyhoeddwyd: (2009)
• Effects of the Bowen-Conradi syndrome mutation in EMG1 on its nuclear import, stability and nucleolar recruitment
  gan: Warda, Ahmed S., et al.
  Cyhoeddwyd: (2016)
• The Bowen–Conradi syndrome protein Nep1 (Emg1) has a dual role in eukaryotic ribosome biogenesis, as an essential assembly factor and in the methylation of Ψ1191 in yeast 18S rRNA
  gan: Meyer, Britta, et al.
  Cyhoeddwyd: (2011)
• EMG1 is essential for mouse pre-implantation embryo development
  gan: Wu, Xiaoli, et al.
  Cyhoeddwyd: (2010)
• The ribosome assembly factor Nep1 responsible for Bowen–Conradi syndrome is a pseudouridine-N1-specific methyltransferase
  gan: Wurm, Jan Philip, et al.
  Cyhoeddwyd: (2010)