Mutation of EMG1 causing Bowen–Conradi syndrome results in reduced cell proliferation rates concomitant with G2/M arrest and 18S rRNA processing delay

Bowen–Conradi syndrome (BCS) is a lethal autosomal recessive disorder caused by a D86G substitution in the protein, Essential for Mitotic Growth 1 (EMG1). EMG1 is essential for 18S rRNA maturation and 40S ribosome biogenesis in yeast, but no studies of its role in ribosome biogenesis have been done...

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Detalhes bibliográficos
Publicado no:BBA Clin
Main Authors: Armistead, Joy, Hemming, Richard, Patel, Nehal, Triggs-Raine, Barbara
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2014
Assuntos:
Regular Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4633970/
https://ncbi.nlm.nih.gov/pubmed/26676230
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbacli.2014.05.002
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