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Efficacy and mechanism of action of the tyrosine kinase inhibitors gefitinib, lapatinib and neratinib in the treatment of HER2-positive breast cancer: preclinical and clinical evidence

An increasing number of tumors, including breast cancer, overexpress proteins of the epidermal growth factor receptor (EGFR) family. The interaction between family members activates signaling pathways that promote tumor progression and resistance to treatment. Human epidermal growth factor receptor...

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Détails bibliographiques
Publié dans:Am J Cancer Res
Auteurs principaux: Segovia-Mendoza, Mariana, González-González, María E, Barrera, David, Díaz, Lorenza, García-Becerra, Rocío
Format: Artigo
Langue:Inglês
Publié: e-Century Publishing Corporation 2015
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4633889/
https://ncbi.nlm.nih.gov/pubmed/26609467
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