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An LSC epigenetic signature is largely mutation independent and implicates the HOXA cluster in AML pathogenesis
Acute myeloid leukaemia (AML) is characterized by subpopulations of leukaemia stem cells (LSCs) that are defined by their ability to engraft in immunodeficient mice. Here we show an LSC DNA methylation signature, derived from xenografts and integration with gene expression that is comprised of 71 ge...
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| Udgivet i: | Nat Commun |
|---|---|
| Main Authors: | , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Nature Pub. Group
2015
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4633733/ https://ncbi.nlm.nih.gov/pubmed/26444494 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms9489 |
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