CRISPR/gRNA-directed synergistic activation mediator (SAM) induces specific, persistent and robust reactivation of the HIV-1 latent reservoirs

Current antiretroviral therapy does not eliminate the integrated and transcriptionally silent HIV-1 provirus in latently infected cells. Recently, a “shock and kill” strategy has been extensively explored to eradicate the HIV-1 latent reservoirs for a permanent cure of AIDS. The therapeutic efficacy...

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Publicado no:Sci Rep
Main Authors: Zhang, Yonggang, Yin, Chaoran, Zhang, Ting, Li, Fang, Yang, Wensheng, Kaminski, Rafal, Fagan, Philip Regis, Putatunda, Raj, Young, Won-Bin, Khalili, Kamel, Hu, Wenhui
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4633726/
https://ncbi.nlm.nih.gov/pubmed/26538064
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep16277
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