Pathophysiology of osteoarthritis: canonical NF-κB/IKKβ-dependent and kinase-independent effects of IKKα in cartilage degradation and chondrocyte differentiation

Osteoarthritis (OA), a whole-joint disease driven by abnormal biomechanics and attendant cell-derived and tissue-derived factors, is a rheumatic disease with the highest prevalence, representing a severe health burden with a tremendous economic impact. Members of the nuclear factor κB (NF-κB) family...

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Bibliographic Details
Published in:RMD Open
Main Authors: Olivotto, Eleonora, Otero, Miguel, Marcu, Kenneth B, Goldring, Mary B
Format: Artigo
Language:Inglês
Published: BMJ Publishing Group 2015
Subjects:
Proceedings from OsteoRheumatology 2014
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4632142/
https://ncbi.nlm.nih.gov/pubmed/26557379
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/rmdopen-2015-000061
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