Whole-Genome Sequencing Suggests Schizophrenia Risk Mechanisms in Humans with 22q11.2 Deletion Syndrome

Chromosome 22q11.2 microdeletions impart a high but incomplete risk for schizophrenia. Possible mechanisms include genome-wide effects of DGCR8 haploinsufficiency. In a proof-of-principle study to assess the power of this model, we used high-quality, whole-genome sequencing of nine individuals with...

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Dettagli Bibliografici
Pubblicato in:G3 (Bethesda)
Autori principali: Merico, Daniele, Zarrei, Mehdi, Costain, Gregory, Ogura, Lucas, Alipanahi, Babak, Gazzellone, Matthew J., Butcher, Nancy J., Thiruvahindrapuram, Bhooma, Nalpathamkalam, Thomas, Chow, Eva W. C., Andrade, Danielle M., Frey, Brendan J., Marshall, Christian R., Scherer, Stephen W., Bassett, Anne S.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Genetics Society of America 2015
Soggetti:
Investigations
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4632064/
https://ncbi.nlm.nih.gov/pubmed/26384369
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1534/g3.115.021345
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