Exact Inference for Hardy-Weinberg Proportions with Missing Genotypes: Single and Multiple Imputation

This paper addresses the issue of exact-test based statistical inference for Hardy−Weinberg equilibrium in the presence of missing genotype data. Missing genotypes often are discarded when markers are tested for Hardy−Weinberg equilibrium, which can lead to bias in the statistical inference about eq...

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Bibliographic Details
Published in:G3 (Bethesda)
Main Authors: Graffelman, Jan, Nelson, S., Gogarten, S. M., Weir, B. S.
Format: Artigo
Language:Inglês
Published: Genetics Society of America 2015
Subjects:
Investigations
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4632056/
https://ncbi.nlm.nih.gov/pubmed/26377959
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1534/g3.115.022111
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