Systems biology-guided identification of synthetic lethal gene pairs and its potential use to discover antibiotic combinations

Mathematical models of metabolism from bacterial systems biology have proven their utility across multiple fields, for example metabolic engineering, growth phenotype simulation, and biological discovery. The usefulness of the models stems from their ability to compute a link between genotype and ph...

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Publicado en:Sci Rep
Autores principales: Aziz, Ramy K., Monk, Jonathan M., Lewis, Robert M., In Loh, Suh, Mishra, Arti, Abhay Nagle, Amrita, Satyanarayana, Chitkala, Dhakshinamoorthy, Saravanakumar, Luche, Michele, Kitchen, Douglas B., Andrews, Kathleen A., Fong, Nicole L., Li, Howard J., Palsson, Bernhard O., Charusanti, Pep
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group 2015
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4631998/
https://ncbi.nlm.nih.gov/pubmed/26531810
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep16025
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