Model-driven discovery of synergistic inhibitors against E. coli and S. enterica serovar Typhimurium targeting a novel synthetic lethal pair, aldA and prpC

Mathematical models of biochemical networks form a cornerstone of bacterial systems biology. Inconsistencies between simulation output and experimental data point to gaps in knowledge about the fundamental biology of the organism. One such inconsistency centers on the gene aldA in Escherichia coli:...

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Publicado no:Front Microbiol
Main Authors: Aziz, Ramy K., Khaw, Valerie L., Monk, Jonathan M., Brunk, Elizabeth, Lewis, Robert, Loh, Suh I., Mishra, Arti, Nagle, Amrita A., Satyanarayana, Chitkala, Dhakshinamoorthy, Saravanakumar, Luche, Michele, Kitchen, Douglas B., Andrews, Kathleen A., Palsson, Bernhard Ø., Charusanti, Pep
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2015
Assuntos:
Microbiology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4585216/
https://ncbi.nlm.nih.gov/pubmed/26441892
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fmicb.2015.00958
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