Model-driven discovery of synergistic inhibitors against E. coli and S. enterica serovar Typhimurium targeting a novel synthetic lethal pair, aldA and prpC

Mathematical models of biochemical networks form a cornerstone of bacterial systems biology. Inconsistencies between simulation output and experimental data point to gaps in knowledge about the fundamental biology of the organism. One such inconsistency centers on the gene aldA in Escherichia coli:...

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Bibliografiska uppgifter
I publikationen:Front Microbiol
Huvudupphovsmän: Aziz, Ramy K., Khaw, Valerie L., Monk, Jonathan M., Brunk, Elizabeth, Lewis, Robert, Loh, Suh I., Mishra, Arti, Nagle, Amrita A., Satyanarayana, Chitkala, Dhakshinamoorthy, Saravanakumar, Luche, Michele, Kitchen, Douglas B., Andrews, Kathleen A., Palsson, Bernhard Ø., Charusanti, Pep
Materialtyp: Artigo
Språk:Inglês
Publicerad: Frontiers Media S.A. 2015
Ämnen:
Microbiology
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4585216/
https://ncbi.nlm.nih.gov/pubmed/26441892
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fmicb.2015.00958
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