The Consequences of Replicating in the Wrong Orientation: Bacterial Chromosome Duplication without an Active Replication Origin

Chromosome replication is regulated in all organisms at the assembly stage of the replication machinery at specific origins. In Escherichia coli, the DnaA initiator protein regulates the assembly of replication forks at oriC. This regulation can be undermined by defects in nucleic acid metabolism. I...

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Detalhes bibliográficos
Publicado no:mBio
Main Authors: Dimude, Juachi U., Stockum, Anna, Midgley-Smith, Sarah L., Upton, Amy L., Foster, Helen A., Khan, Arshad, Saunders, Nigel J., Retkute, Renata, Rudolph, Christian J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Microbiology 2015
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4631800/
https://ncbi.nlm.nih.gov/pubmed/26530381
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/mBio.01294-15
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