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Exploring the HIFs, buts and maybes of hypoxia signalling in disease: lessons from zebrafish models

A low level of tissue oxygen (hypoxia) is a physiological feature of a wide range of diseases, from cancer to infection. Cellular hypoxia is sensed by oxygen-sensitive hydroxylase enzymes, which regulate the protein stability of hypoxia-inducible factor α (HIF-α) transcription factors. When stabilis...

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Foilsithe in:Dis Model Mech
Main Authors: Elks, Philip M., Renshaw, Stephen A., Meijer, Annemarie H., Walmsley, Sarah R., van Eeden, Fredericus J.
Formáid: Artigo
Teanga:Inglês
Foilsithe: The Company of Biologists 2015
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4631790/
https://ncbi.nlm.nih.gov/pubmed/26512123
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dmm.021865
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