Resveratrol compounds inhibit human holocarboxylase synthetase and cause a lean phenotype in Drosophila melanogaster

Holocarboxylase synthetase (HLCS) is the sole protein-biotin ligase in the human proteome. HLCS has key regulatory functions in intermediary metabolism, including fatty acid metabolism, and in gene repression through epigenetic mechanisms. The objective of this study was to identify foodborne inhibi...

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Detalhes bibliográficos
Publicado no:J Nutr Biochem
Main Authors: Cordonier, Elizabeth L., Adjam, Riem, Camara Teixeira, Daniel, Onur, Simone, Zbasnik, Richard, Read, Paul E., Döring, Frank, Schlegel, Vicki L., Zempleni, Janos
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4631641/
https://ncbi.nlm.nih.gov/pubmed/26303405
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jnutbio.2015.07.004
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