Resveratrol compounds inhibit human holocarboxylase synthetase and cause a lean phenotype in Drosophila melanogaster

Holocarboxylase synthetase (HLCS) is the sole protein-biotin ligase in the human proteome. HLCS has key regulatory functions in intermediary metabolism, including fatty acid metabolism, and in gene repression through epigenetic mechanisms. The objective of this study was to identify foodborne inhibi...

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I publikationen:J Nutr Biochem
Huvudupphovsmän: Cordonier, Elizabeth L., Adjam, Riem, Camara Teixeira, Daniel, Onur, Simone, Zbasnik, Richard, Read, Paul E., Döring, Frank, Schlegel, Vicki L., Zempleni, Janos
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2015
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4631641/
https://ncbi.nlm.nih.gov/pubmed/26303405
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jnutbio.2015.07.004
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