Interferon-α Subtypes in an Ex Vivo Model of Acute HIV-1 Infection: Expression, Potency and Effector Mechanisms

HIV-1 is transmitted primarily across mucosal surfaces and rapidly spreads within the intestinal mucosa during acute infection. The type I interferons (IFNs) likely serve as a first line of defense, but the relative expression and antiviral properties of the 12 IFNα subtypes against HIV-1 infection...

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Detalhes bibliográficos
Publicado no:PLoS Pathog
Main Authors: Harper, Michael S., Guo, Kejun, Gibbert, Kathrin, Lee, Eric J., Dillon, Stephanie M., Barrett, Bradley S., McCarter, Martin D., Hasenkrug, Kim J., Dittmer, Ulf, Wilson, Cara C., Santiago, Mario L.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2015
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4631339/
https://ncbi.nlm.nih.gov/pubmed/26529416
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1005254
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