Human hepatocyte assessment of imatinib drug–drug interactions – complexities in clinical translation

AIM: Inducers and inhibitors of CYP3A, such as ritonavir and efavirenz, may be used as part of the highly active antiretroviral therapy (HAART) to treat HIV patients. HIV patients with chronic myeloid leukemia or gastrointestinal stromal tumour may need imatinib, a CYP3A4 substrate with known exposu...

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Detalhes bibliográficos
Publicado no:Br J Clin Pharmacol
Main Authors: Beumer, Jan H, Pillai, Venkateswaran C, Parise, Robert A, Christner, Susan M, Kiesel, Brian F, Rudek, Michelle A, Venkataramanan, Raman
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley & Sons, Ltd 2015
Assuntos:
Drug Interactions
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4631182/
https://ncbi.nlm.nih.gov/pubmed/26178713
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bcp.12723
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