Physiologically-based pharmacokinetic modeling of renally excreted antiretroviral drugs in pregnant women

AIM: Physiological changes during pregnancy can affect drug disposition. Anticipating these changes will help to maximize drug efficacy and safety in pregnant women. Our objective was to determine if physiologically-based pharmacokinetics (PBPK) can accurately predict changes in the disposition of r...

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Veröffentlicht in:Br J Clin Pharmacol
Hauptverfasser: De Sousa Mendes, Maïlys, Hirt, Deborah, Urien, Saik, Valade, Elodie, Bouazza, Naïm, Foissac, Frantz, Blanche, Stephane, Treluyer, Jean-Marc, Benaboud, Sihem
Format: Artigo
Sprache:Inglês
Veröffentlicht: John Wiley & Sons, Ltd 2015
Schlagworte:
Pharmacokinetics
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4631176/
https://ncbi.nlm.nih.gov/pubmed/26011128
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bcp.12685
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