The role of p19 and p21 H-Ras proteins and mutants in miRNA expression in cancer and a Costello syndrome cell model

BACKGROUND: P19 H-Ras, a second product derived from the H-Ras gene by alternative splicing, induces a G1/S phase delay, thereby maintaining cells in a reversible quiescence state. When P21 H-Ras is mutated in tumour cells, the alternative protein P19 H-Ras is also mutated. The H-Ras mutation Q61L i...

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Detalhes bibliográficos
Publicado no:BMC Med Genet
Main Authors: García-Cruz, Roseli, Camats, Maria, Calin, George A., Liu, Chang-Gong, Volinia, Stefano, Taccioli, Cristian, Croce, Carlo M., Bach-Elias, Montse
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2015
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4631104/
https://ncbi.nlm.nih.gov/pubmed/26138095
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12881-015-0184-z
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