Targeting translocator protein (18 kDa) (TSPO) dampens pro-inflammatory microglia reactivity in the retina and protects from degeneration

BACKGROUND: Reactive microglia are commonly seen in retinal degenerative diseases, and neurotoxic microglia responses can contribute to photoreceptor cell death. We and others have previously shown that translocator protein (18 kDa) (TSPO) is highly induced in retinal degenerations and that the sele...

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Detalhes bibliográficos
Publicado no:J Neuroinflammation
Main Authors: Scholz, Rebecca, Caramoy, Albert, Bhuckory, Mohajeet B., Rashid, Khalid, Chen, Mei, Xu, Heping, Grimm, Christian, Langmann, Thomas
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2015
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4630900/
https://ncbi.nlm.nih.gov/pubmed/26527153
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12974-015-0422-5
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