Minocycline counter-regulates pro-inflammatory microglia responses in the retina and protects from degeneration

BACKGROUND: Microglia reactivity is a hallmark of retinal degenerations and overwhelming microglial responses contribute to photoreceptor death. Minocycline, a semi-synthetic tetracycline analog, has potent anti-inflammatory and neuroprotective effects. Here, we investigated how minocycline affects...

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Dettagli Bibliografici
Pubblicato in:J Neuroinflammation
Autori principali: Scholz, Rebecca, Sobotka, Markus, Caramoy, Albert, Stempfl, Thomas, Moehle, Christoph, Langmann, Thomas
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2015
Soggetti:
Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4650866/
https://ncbi.nlm.nih.gov/pubmed/26576678
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12974-015-0431-4
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