Загрузка...
Unlike Catalyzing Error-Free Bypass of 8-oxodGuo, DNA Polymerase λ Is Responsible for a Significant Part of Fapy•dG-Induced G→T Mutations in Human Cells
8-OxodGuo and Fapy•dG induced 10–22% mutations, predominantly G→T transversions, in HEK 293T cells in four TG*N sequence contexts, where N = C, G, A, or T. siRNA knockdown of pol λ resulted in a 34% and 55% increase in mutations in the progeny from the 8-oxodGuo construct in the TG*T and TG*G sequen...
Сохранить в:
| Опубликовано в: : | Biochemistry |
|---|---|
| Главные авторы: | , , , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2015
|
| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4630799/ https://ncbi.nlm.nih.gov/pubmed/25741586 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.5b00119 |
| Метки: |
Добавить метку
Нет меток, Требуется 1-ая метка записи!
|