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Unlike Catalyzing Error-Free Bypass of 8-oxodGuo, DNA Polymerase λ Is Responsible for a Significant Part of Fapy•dG-Induced G→T Mutations in Human Cells
8-OxodGuo and Fapy•dG induced 10–22% mutations, predominantly G→T transversions, in HEK 293T cells in four TG*N sequence contexts, where N = C, G, A, or T. siRNA knockdown of pol λ resulted in a 34% and 55% increase in mutations in the progeny from the 8-oxodGuo construct in the TG*T and TG*G sequen...
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| 出版年: | Biochemistry |
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| 主要な著者: | , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2015
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4630799/ https://ncbi.nlm.nih.gov/pubmed/25741586 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.5b00119 |
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