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Adrenergic stimulation sensitizes TRPV1 through upregulation of cystathionine β-synthetase in a rat model of visceral hypersensitivity

The pathogenesis of pain in irritable bowel syndrome (IBS) is poorly understood and treatment remains difficult. The present study was designed to investigate roles of adrenergic signaling and the endogenous hydrogen sulfide producing enzyme cystathionine β-synthetase (CBS) in a previously validated...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Zhu, Liyan, Zhao, Liting, Qu, Ruobing, Zhu, Hong-Yan, Wang, Yongmeng, Jiang, Xinghong, Xu, Guang-Yin
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4630780/
https://ncbi.nlm.nih.gov/pubmed/26527188
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep16109
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